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KMID : 1007520170260030847
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Food Science and Biotechnology
2017 Volume.26 No. 3 p.847 ~ p.852
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Antifungal activity of isothiocyanates extracted from horseradish (Armoracia rusticana) root against pathogenic dermal fungi
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Choi Kyu-Duck
Kim Hee-Yeon
Shin Il-Shik
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Abstract
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To develop natural antifungal agents against pathogenic dermal fungi, the antifungal activity of isothiocyanates (ITCs) extracted from horseradish (Armoracia rusticana) root was investigated. A paper disk diffusion assay showed that ITCs inhibited growth of the four pathogenic dermal fungi (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, and Epidermophyton floccosum) at 5000 μg/mL, as well as perfectly inhibited the growth of the fungi at 10,000 μg/mL in a concentration-dependent manner. The minimum inhibitory concentrations of ITCs against T. rubrum, T. mentagrophytes, M. canis, and E. floccosum were 200, 200, 100, and 100 μg/mL, respectively. The minimum fungicidal concentrations of ITCs against the four pathogenic dermal fungi were 200 μg/mL. These results strongly suggested that ITCs extracted from horseradish root can be a candidate of natural antifungal agents against pathogenic dermal fungi, even though further study is needed to investigate how to use ITCs in clinical therapy.
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KEYWORD
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Antifungal activity, Isothiocyanates, Dermatophytes, MIC, MFC
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